7th PCB Workshop:
Chemical Mixtures in a Complex World
May 27, 2012 Sunday
6.00 pm Sunday Evening Reception: Address to participants and
7.00 pm Honorary lecture by J.F. Narbonne in celebration of his retirement: “25 years of PCB risk assessment in France
May 28, 2012 Monday
Session I (morning): Origin, analysis, Levels in environment compartments
Chairs: Keri Hornbuckle and Bruno Lebizec
9.00 am Dr. Amina Salamova "Polychlorinated Biphenyls (PCBs) in the Great Lakes’ Atmosphere"
9.30 am Dr. Geniece M. Lehmann "Evaluating non-cancer health risk from inhaled PCBs: Uncertainties and research needs"
10.00 am Dr. Benoit Van Aken "Biodegradation of PCBs and their hydroxylated metabolites"
10.30 am Coffee break
11.00 am Dr. Keri Hornbuckle "Sources of PCB congeners in urban, industrial, rural and indoor environments"
11.30 am Dr. Bruno Le Bizec
12.00 pm Selected Posters Presentation
12:45 pm Lunch
Goal of the session: Identification and quantification of current sources of PCBs, levels in atmosphere, soil and water, transfer in the food web.
Session II (afternoon) : Mechanism of Action and Metabolite Interactions
Chairs: Michael Duffel and Jean-Pierre Cravedi
2.00 pm Michael Duffel “Metabolism of PCBs with an Emphasis on the Potential Roles of Sulfation in Toxicity and Endocrine Disruption”
2.30 pm Jean Pierre Cravedi "Biotransformation of PBDEs and Other Polybrominated Compounds: Evidence for Bioactivation Pathways and Comparison with PCBs"
3.00 pm Coffee break
3.15 pm Bernhard Hennig "Influence of Nutrition in Mechanisms of PCB toxicity"
3.45 pm Gabriele Ludewig “Genotoxic endpoints and exposure to PCBs: Unique effects by different PCBs and metabolites”
Goal of the session: Recent knowledge on the metabolism and mechanism of action of polyhalogenated compounds, interactions at the receptors level, agonist and antagonist effects, interactions of parent compounds and metabolites.
5.00 pm Boat trip to Cap Ferret
5.30 pm Bike trip (or bus) to Arès
7.00 pm Oyster party
10.00 pm Trip back to Arcachon (by bus)
May 29, 2012 Tuesday
Session III (morning): Health effects/critical limits
Chairs: Jean François Narbonne and Isaac Pessah
9.00 am Ellen Fritsche "Pathway-and Species-specific Effects of Different POPS on Neurosphere Development in vitro"
9.30 am Pamela Lein “Polychlorinated Biphenyls (PCBs) Modulate Neuronal Connectivity via Ryanodine Receptor Dependent Mechanisms”
10.00 am Remco Westerink “Modulation of neutrotransmitter-and voltage-gated ion channels by PCBs and other POPs”
10.30 am Coffee break
11.00 am Rich Seegal “Sexually Dimorphic Effects of PCBs -From Neurodevelopment to Neurodegeneration”
11.30 am Isaac Pessah: "Strategic Models for Understanding Gene X Environment Interactions Conferring PCB Susceptibility"
12.00 pm Miroslav Machala et al "In vitro assessment of toxic potencies of PCBs - old and novel mechanisms"
12.30 pm Rachid Soulimani " Methodology for the neurotoxic effects assessment of exposure to low doses of NDL-PCB mixtures in the early stages of development"
12.55 pm Lunch
Goal of the session: Tentative of setting biological limits for critical health effects for general and specific populations
Session IV (afternoon): Human exposure and Human biomonitoring
Chairs: Jean Charles Leblanc, Nadine Fréry
2.00 pm Fanny Héraud "PCB exposure via food in Europe"
2.30 pm Rainer Malisch “Results of WHO/UNEP-coordinated exposure studies on levels of PCDD/F and PCBs (dioxin-like and non dioxin-like) and in human milk"
3.00 pm Nadine Fréry & Jean-Charles Leblanc French studies: "PCB biomonitoring in general and specific populations in France"
3.30 pm Coffee break
4.00 pm Peter S. Thorne "The AESOP Study: Assessing Exposure to PCBs in Children and their Mothers in At-Risk and Baseline Communities"
4.30 pm Mohamed Ridha Driss “PCB levels in the Tunisian population”
5.00 - 6.30 pm Selected Posters Presentation (sessions II, III, IV)
Goal of the session: Results of exposure studies from food and other sources, relationship with human monitoring programs
7.30 pm Banquet & Music
May 30, 2012 Wednesday
Session V (morning): Special Problems of PCBs in African countries; A shift of sources of PCBs?
Chairs: Rosalinda Gioia, Annie Sasco
9.00 am Rosalinda Gioia "Introduction of the topic"
9.10 am Abidemi Akindele "Persistent Organic Pollutants in Africa: Environmental and Human Health Considerations"
9.40 am Kwadwo Ansong Asante "Contamination by PCBs and BFRs and Human Health Risk Assessment in Fish and Human Breast Milk in Ghana"
10.10 am Coffee break
10.40 am Sunday Adebsoye "Metabolic potentials of PCB-degrading organisms from Nigerian contaminated systems: thus far, where further"
11.10 am Alfons Buekens "Technical, environmental and social factors in PCB management"
11.40 am Annie Sasco "Conclusions/Needs/Directions"
12.00 pm Selected Posters Presentation (sessions V, VI)
13.00 pm Lunch
Goal of the session: Presence of stockpiles of PCBs in African and southern countries in terms of risk evaluation environmental and public health consequences, solutions for elimination and remediation
Session VI (afternoon): Risk issues
Chairs: David Osterberg and Pierre-Marie Badot
2.00 pm Pierre-Marie Badot "State of the art and rationalization on the variety of risk/regulatories approaches used in different countries to access mixtures of chemicals: the case-study of PCB"
2.30 pm Nancy Hopf "Concentration-dependent Half-Lives of Polychlorinated Biphenyl in Sera from an Occupational Cohort"
3.00 pm Geniece M. Lehmann "Evaluating non-cancer health risk from inhaled PCBs: current U.S. perspectives"
3.30 pm Coffee break
4.00 pm Takeshi Nakano "The way Japan deals with PCBs regulations and risk"
4.30 pm Niklas Johanson "The PCB Elimination Network (PEN) initiative of the Stockholm Convention: Recent Activity"
5.00 pm Beatrice Sécrétan "Plans for the IARC monograph on PCBs"
5.15 pm Closing comments
Goal of the session: Approaches for risk assessment: TDI, TEF, specific mixtures, AD AE? What the best methodology for mixtures evaluation
Satellite symposium: May 31, 2012
Agora University Bordeaux Talence
Programmes nationaux sur les contaminations par les PCBs / French National Programs on the contamination by PCBs (présentations en Français avec traduction en anglais)
Introduction : Historique de la surveillance des PCB en France (197262011) / history of PCB monitoring in France (1972-2011)
Session 1 : PCB transfer in environmental compartments
- Aquatic compartments: sediments, molluscs, fish, Rivers, Coasts, Estuaries (ONEMA, Cemagref, Ifremer)
- Terrestrial compartments: Soil, vegetables, animals (INRA, INERIS, ANSES)
Session 2 : Human exposure
- Food exposure (ANSES)
- Human monitoring (InVS)
Session 3 : Recommendations
- Risk assessment/management
- Monitoring / Bioassays
Conclusions and summary